Venlafaxine & Metabolite
Test Mnemonic
VENLA
CPT Codes
- 80338 - QTY (1)
Aliases
- Effexor
Includes
- Venlafaxine Serum/Plasma
- O-Desmethylvenlafaxine Serum/Plasma
- Total Venlafaxine and Metabolite S/P
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Refrigerated | Pre-dose (trough) draw - At steady state concentration. Do not use serum separator tubes. Separate serum from cells ASAP or within 2 hours of collection and transfer to standard aliquot tube. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | EDTA (Lavender) | Refrigerated | Pre-dose (trough) draw - At steady state concentration. Separate plasma from cells ASAP or within 2 hours of collection and transfer to standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 2 weeks |
| Refrigerated | 2 weeks |
| Frozen | 2 weeks |
Days Performed
Wed, Sat
Turnaround Time
2 - 9 days
Methodology
| Name | Description |
|---|---|
| Quantitative Liquid Chromatography - Tandem Mass Spectrometry |
Reference Range
| Total Venlafaxine and Metabolite S/P | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Therapeutic 195 - 400 | ng/mL | Normal | Toxic: Greater than or equal to 800 | ng/mL |
Special Info
Pre-dose (trough) draw - At steady state concentration. Whole blood and gel separator tubes will be rejected. This test is New York DOH approved.
Clinical Info
This test is useful to optimize drug therapy and monitor patient adherence. The therapeutic range is based on serum pre-dose (trough) draw at steady-state concentration. Adverse effects to venlafaxine therapy may include nausea, vomiting, dizziness, tremor and blurred vision.