Synthetic Glucocorticoid Screen, Urine
Test Mnemonic
UGLUCO
CPT Codes
- 80299 - QTY (1)
Includes
- Prednisolone
- Prednisone
- Triamcinolone acetonide
- Betamethasone
- Budesonide
- Dexamethasone
- Fludrocortisone
- Megestrol acetate
- Methylprednisolone
Performing Laboratory
Mayo Clinic Dpt of Lab Med & Pathology
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 5 mL | Urine, random | Clean container | Frozen |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.6 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Unacceptable |
| Refrigerated | Unacceptable |
| Frozen | 14 days |
Days Performed
Wed
Turnaround Time
6 - 12 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) | |
| Stable Isotope Dilution |
Reference Range
| Betamethasone | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative | |||||
| Budesonide | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative | |||||
| Dexmethasone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative | |||||
| Fludrocortisone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative | |||||
| Magestrol Acetate | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative | |||||
| Methylprednisolone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative | |||||
| Prednisolone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative | |||||
| Prednisone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative | |||||
| Triamcinolone Acetonide | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Negative |
Special Info
This test is New York State approved.
Clinical Info
This test is useful for confirming the presence of the listed synthetic glucocorticoids and the cause of secondary adrenal insufficiency. Cutoff Concentrations: Betamethasone: 0.10 mcg/dL; Budesonide: 0.10 mcg/dL; Dexamethasone: 0.10 mcg/dL; Fludrocortisone: 0.10 mcg/dL; Megestrol acetate: 0.10 mcg/dL; Methylprednisolone: 0.10 mcg/dL; Prednisolone: 0.10 mcg/dL; Prednisone: 0.10 mcg/dL; Triamcinolone acetonide: 0.10 mcg/dL. Lack of detection does not preclude use of synthetic glucocorticoid because adrenal suppression may persist for some time after the exogenous steroid is discontinued. This assay cannot detect all of the available synthetic steroids either available as pharmaceutical compounds or chemicals present in food. This assay confirms only the listed synthetic glucocorticoids.