Sequential Scn First Trimester
Test Mnemonic
SEQ1
CPT Codes
- 84702 - QTY (1)
- 84163 - QTY (1)
Includes
- Pregnancy-associated plasma protein (PAPP-A)
- Human chorionic gonadotropin (hCG)
- Down Syndrome Screening Risk
- Trisomy 18 Screening Risk
- Down Syndrome Age Related Risk
- Trisomy 18 Age Related Risk
Performing Laboratory
Integrated Genetics/Labcorp
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Serum | SST (Gold) | Ambient | Specimen MUST be drawn between 10.4 - 13.9 weeks gestation. A nuchal translucency (NT) measurement by a FMF or SMFM certified sonographer MUST be included with specimen. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 7 days |
| Refrigerated | 14 days |
| Frozen | 14 days, 3 freeze/thaw cycles |
Days Performed
Mon - Fri
Turnaround Time
3 - 6 days
Methodology
| Name | Description |
|---|---|
| Chemiluminescence Immunoassay (CLIA) |
Reference Range
| Sequential Screen 1 Interpretation | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Final result pending second trimester sample |
Special Info
PLEASE NOTE: The performing lab will accept nuchal translucency (NT) measurements only from sonographers certified by the Fetal Medicine Foundation (FMF) or the Society for Maternal Fetal Medicine (SMFM). Please submit certification information before sending specimens for Sequential Screen. Submit an Integrated Genetics requisition. Complete clinical and patient information is required for reporting including: Gravida, Para, SAB, TAB, Ultrasound date, Ultrasound fetal age, Sonographer, NT, CRL, LMP date, EDC date, IVF fertilization date, IVF egg donor age (if applicable), maternal weight, number of fetuses, insulin-dependent diabetic prior to pregnancy?, previous down syndrome pregnancy/child?, family history of NTD?, physician or designee signature.
Clinical Info
Sequential Screen is a two part test that screens for fetal Down syndrome, trisomy 18, and open neural tube defects.