PTT Incubated Mixing Study | Cleveland Clinic Laboratories

PTT Incubated Mixing Study Print

Test Mnemonic

PTTIM

CPT Codes

85730 - QTY (1)
85610 - QTY (1)
85670 - QTY (1)
85520 - QTY (1)
85390 - QTY (1)

Aliases

APTT Mixing Study
CAC
CACLA
Circulating Anticoagulant
PTT Correction Study
PTT Mixing Study
APTT Incubated Mixing Study

Includes

PT Screen
APTT Screen
Thrombin Time
Heparin Anti Xa Assay

Performing Laboratory

Cleveland Clinic Laboratories

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
6 mL	Plasma	Sodium citrate (Lt. Blue)		Centrifuge, aliquot and freeze ASAP.	Collection tubes must be filled to total fill volume. Inadequately filled tubes will be rejected. Non-testing sites: Centrifuge samples; Aliquot plasma into a separate tube and label with Epic Beaker labels. Specimens should be frozen (-20C or colder).

Minimum Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
2 mL					Minimum is 2 mL of plasma. NOTE: If only the minimum volume is received, some reflex testing may not be able to be performed.

Stability

Environmental Condition	Description
Ambient	Main campus: ACCEPTABLE for Whole Blood. (Must be delivered ambient to testing lab less than 4 hours post collection.) Non-Testing Sites: UNACCEPTABLE.
Refrigerated	Unacceptable
Frozen	For Non-Testing sites, Frozen Plasma is ACCEPTABLE. (Centrifuge samples, then aliquot plasma into a separate tube and label with Epic Beaker labels. Specimens should be frozen (-20° C or colder) and they are stable for 2 weeks. (6 months at -70 C)

Days Performed

Mon - Fri

Turnaround Time

1 - 3 days

Methodology

Name	Description
Clot Detection

Reference Range

APTT Screen
Sex	Age From	Age To	Type	Range	Range Unit
	Days	1 Days	Normal	28.2-47.4	sec
	2 Days	5 Days	Normal	22.9-52.0	sec
	6 Days	30 Days	Normal	23.1-48.0	sec
	1 Months	3 Months	Normal	21.7-43.5	sec
	4 Months	11 Months	Normal	25.3-37.3	sec
	17 Years	99 Years	Normal	24.0-35.1	sec
	1 Years	5 Years	Normal	21.3-31.6	sec
	6 Years	10 Years	Normal	23.1-31.6	sec
	11 Years	16 Years	Normal	23.1-32.5	sec
PT Screen
Sex	Age From	Age To	Type	Range	Range Unit
	Days	1 Days	Normal	< 14.9	sec
	2 Days	5 Days	Normal	< 14.3	sec
	6 Days	30 Days	Normal	< 13.4	sec
	1 Months	3 Months	Normal	< 13.3	sec
	4 Months	11 Months	Normal	< 13.0	sec
	17 Years	99 Years	Normal	< 13.1	sec
	1 Years	5 Years	Normal	< 10.7	sec
	6 Years	10 Years	Normal	< 11.3	sec
	11 Years	16 Years	Normal	< 11.2	sec
Thrombin Time
Sex	Age From	Age To	Type	Range	Range Unit
	Days	1 Days	Normal	< 17.3	sec
	1 Years	999 Years	Normal	< 18.6	sec
	4 Months	11 Months	Normal	< 19.1	sec
	1 Months	3 Months	Normal	< 18.2	sec
	6 Days	30 Days	Normal	< 17.9	sec
	2 Days	5 Days	Normal	< 17.9	sec

Special Info

If tests are abnormal in the panel, the following tests may be ordered and billed: PTT Immediate and 1 Hour Incubated Mix (85732 x2), Factor II (85210), Factor V (85220), Factor VII (85230), Factor X (85260), Factor VIII (85247), Factor VIII Chromogenic (85240), Factor IX Assay (85250), Factor XI Assay (85270), Factor XII Assay (85280), Reptilase Time (85635), D-Dimer (85379), von Willebrand Factor Antigen (85246), Platelet Neutralization (85597), Ristocetin Co-Factor (85245), Bethesda Inhibitor (85335), Dilute Russell Viper Venom Time (85613 x2), Hexagonal Phase Phospholipid Neutralization (85730 & 85598), Fibrinogen (85384) & Fibrinogen Ag (85385).

Clinical Info

To distinguish a coagulation factor deficiency from an inhibitor.

Technical Brief

Mixing Study, Incubated APTT