Olanzapine
Test Mnemonic
OLANZ
CPT Codes
- 80299 - QTY (1)
LOINC ®
12389-3
Includes
- Olanzapine
Performing Laboratory
ARUP
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Serum | No additive (Red) | Frozen, Critical | Do not use serum separator tubes. Separate serum from cells within 2 hours of collection and freeze. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Plasma | EDTA (Lavender) | Frozen, Critical | Separate plasma from cells within 2 hours of collection and freeze. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Unacceptable |
| Refrigerated | Unacceptable |
| Frozen | 1 month |
Days Performed
Tue, Fri
Turnaround Time
2 - 8 days
Methodology
| Name | Description |
|---|---|
| Quantitative Liquid Chromatography - Tandem Mass Spectrometry |
Reference Range
| Olanzapine | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | Therapeutic Range: 20-80 | ng/mL | Normal | Toxic: Greater than or equal to 100 | ng/mL |
Special Info
Specimen should be collected prior to next dose - at steady state concentration. Hemolyzed specimens will be rejected.
Clinical Info
Olanzapine is an antipsychotic drug indicated for the treatment of depression and bipolar disorder. The therapeutic range is based on serum, predose (trough) draw collection at steady-state concentration. Adverse effects may include dizziness, akathisia, postural hypotension, delirium, somnolence, neuroleptic malignant syndrome, hyperglycemia, and agitation. Noroxycodone causes an analytical interference and impacts the quantitation of Olanzapine.