Neurotransmitter Metabolites/Amines | Cleveland Clinic Laboratories

Neurotransmitter Metabolites/Amines Print

Test Mnemonic

NEUR

CPT Codes

83497 - QTY (1)
83150 - QTY (1)
82542 - QTY (1)

Includes

5-Hydroxyindoleacetic acid
Homovanillic acid
3-o-methydopa

Performing Laboratory

Medical Neurogenetics

FDA Category

Laboratory Developed Test

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
4.5 mL	Cerebrospinal fluid (CSF)	Set of 5 MNG Collection Tubes		Frozen	CSF should be collected from the first drop into the containers in the order indicated. Fill each tube to the marked line (0.5 mL in tube 1; 1.0 mL in tubes 2, 3, 4, and 5). Place specimens on ice after collection. If specimen is blood contaminated, the tubes should be centrifuged immediately (prior to freezing) and the clear CSF transferred to new similarly labeled tubes then frozen ASAP at -80 C. Call Client Services at 216-444-5755 or 800-628-6816 to obtain sample collection tubes.

Stability

Environmental Condition	Description
Ambient	Unacceptable
Refrigerated	Unacceptable
Frozen	Indefinitely

Days Performed

Tue - Fri

Turnaround Time

15 - 17 days

Methodology

Name	Description
High Performance Liquid Chromatography with Electrochemical Detection

Reference Range

3-O-methyldopa
Sex	Age From	Age To	Type	Range	Range Unit
	Years	2 Years	Normal	<300	nmol/L
	2 Years	5 Years	Normal	<150	nmol/L
	5 Years	15 Years	Normal	<100	nmol/L
				Adults: <100 nmol/L
5-Hydroxyindoleacetic acid
Sex	Age From	Age To	Type	Range	Range Unit
	Months	2 Months	Normal	208-1159	nmol/L
	2 Months	6 Months	Normal	179-711	nmol/L
	6 Months	24 Months	Normal	129-520	nmol/L
	2 Years	5 Years	Normal	74-345	nmol/L
	5 Years	10 Years	Normal	66-338	nmol/L
	10 Years	15 Years	Normal	67-189	nmol/L
				Adults: 67-140 nmol/L
Homovanillic acid
Sex	Age From	Age To	Type	Range	Range Unit
	Months	2 Months	Normal	337-1299	nmol/L
	2 Months	6 Months	Normal	450-1132	nmol/L
	6 Months	24 Months	Normal	294-1115	nmol/L
	2 Years	5 Years	Normal	233-928	nmol/L
	5 Years	10 Years	Normal	218-852	nmol/L
	10 Years	15 Years	Normal	167-563	nmol/L
				Adults: 145-324 nmol/L

Special Info

Call Client Services to obtain appropriate sample collection containers. Each set consists of 5 numbered centrifuge tubes in a small plastic bag. Tube #3 contains antioxidants necessary to protect the sample from oxidation. One set of tubes is required per patient.