Myeloid Panel NGS Bone Marrow




Test Mnemonic

MYNGSM

CPT Codes

  • 81455 - QTY (1)

Aliases

  • Chronic Myeloid Neoplasm Panel Bone Marrow
  • CSF3R
  • SF3B1

Performing Laboratory

Cleveland Clinic Laboratories

FDA Category

Laboratory Developed Test


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
Volume4 mLTypeAspirate, bone marrowContainerEDTA (Lavender)Collect TemperatureAmbientTransport TemperatureRefrigeratedSpecial Instructions 

Stability

Environmental Condition Description
Environmental ConditionAmbientDescriptionIf specimen is to be stored longer than 24 hours, it should be placed at 2-8 C for up to 7 days.
Environmental ConditionFrozenDescriptionUNACCEPTABLE
Environmental ConditionRefrigeratedDescription7 days

Turnaround Time

10 days

Methodology

Name Description
NameNext Generation DNA SequencingDescription 

Special Info

The following genes are interrogated: ABL, ASXL1, BCOR, BCORL1, BRAF, CALR, CBL, CDKN2A, CEBPA, CSF3R, CUX1, DDX41, DNMT3A, EED, ETNK1, ETV6, EZH2, FBXW7, FLT3, GATA1, GATA2, GNAS, IDH1, IDH2, IKZF1, JAK2, JAK3, KDM6A, KIT, KMT2A, KRAS, LUC7L2, MPL, MYD88, NF1, NOTCH1, NPM1, NRAS, PAX5, PHF6, PIGA, PPMID, PRPF8, PTEN, PTPN11, RAD2, RIT1, RUNX1, SETBP1, SF3B1, SH2B3, SMC1A, SMC3, SRSF2, STAG2, STAT3, STAT5B, SUZ12, TET2, TP53, U2AF1, WT1, and ZRSR2.

Clinical Info

Molecular evaluation of known or suspected chronic myeloid neoplasms, including but not limited to myeloproliferative neoplasms, myelodysplastic syndromes, and overlap myelodysplastic/myeloproliferative neoplasms. Evaluates for single nucleotide variants, small insertions and deletions within the covered regions of the targeted genes.

Clinical Limitation

This test does not evaluate for fusions. For a combined evaluation including fusions relevant to acute leukemias, the Acute Leukemia NGS panel is recommended.