Myeloid Panel NGS Bone Marrow
Test Mnemonic
MYNGSM
CPT Codes
- 81455 - QTY (1)
Aliases
- Chronic Myeloid Neoplasm Panel Bone Marrow
- CSF3R
- SF3B1
Performing Laboratory
Cleveland Clinic Laboratories
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4 mL | Aspirate, bone marrow | EDTA (Lavender) | Ambient | Refrigerated |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | If specimen is to be stored longer than 24 hours, it should be placed at 2-8 C for up to 7 days. |
| Frozen | UNACCEPTABLE |
| Refrigerated | 7 days |
Turnaround Time
10 days
Methodology
| Name | Description |
|---|---|
| Next Generation DNA Sequencing |
Special Info
The following genes are interrogated: ABL, ASXL1, BCOR, BCORL1, BRAF, CALR, CBL, CDKN2A, CEBPA, CSF3R, CUX1, DDX41, DNMT3A, EED, ETNK1, ETV6, EZH2, FBXW7, FLT3, GATA1, GATA2, GNAS, IDH1, IDH2, IKZF1, JAK2, JAK3, KDM6A, KIT, KMT2A, KRAS, LUC7L2, MPL, MYD88, NF1, NOTCH1, NPM1, NRAS, PAX5, PHF6, PIGA, PPMID, PRPF8, PTEN, PTPN11, RAD2, RIT1, RUNX1, SETBP1, SF3B1, SH2B3, SMC1A, SMC3, SRSF2, STAG2, STAT3, STAT5B, SUZ12, TET2, TP53, U2AF1, WT1, and ZRSR2.
Clinical Info
Molecular evaluation of known or suspected chronic myeloid neoplasms, including but not limited to myeloproliferative neoplasms, myelodysplastic syndromes, and overlap myelodysplastic/myeloproliferative neoplasms. Evaluates for single nucleotide variants, small insertions and deletions within the covered regions of the targeted genes.
Clinical Limitation
This test does not evaluate for fusions. For a combined evaluation including fusions relevant to acute leukemias, the Acute Leukemia NGS panel is recommended.