Methadone & Metabolite
Test Mnemonic
MMTAB
CPT Codes
- 80358 - QTY (1)
- G0480 - QTY (1)
LOINC ®
Not available
Aliases
- Dolophine
Includes
- Methadone
- EDDP (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine)
Performing Laboratory
ARUP
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | Potassium oxalate/sodium fluoride (Gray) | Refrigerated | Separate plasma from cells ASAP or within 2 hours of collection and transfer into standard aliquot tube. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Refrigerated | Do not use serum separator tubes. Separate serum from cells ASAP or within 2 hours of collection and transfer into standard aliquot tube. | |
| 1 mL | Plasma | Sodium heparin (Green) | Refrigerated | Do not use plasma separator tubes. Separate plasma from cells ASAP or within 2 hours of collection and transfer into standard aliquot tube. | |
| 1 mL | Plasma | EDTA (Lavender) | Refrigerated | Separate plasma from cells ASAP or within 2 hours of collection and transfer into standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 1 week |
| Refrigerated | After separation from cells: 2 weeks |
| Frozen | After separation from cells: 3 years (Avoid repeated freeze/thaw cycles) |
Days Performed
Sun - Sat
Turnaround Time
2 - 8 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
Reference Range
| Methadone | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff: 10 ng/mL | |||||
| Methadone Metabolite | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff: 10 ng/mL |
Special Info
Separator tubes, plasma or whole blood collected in sodium citrate (light blue) tubes, specimens exposed to repeated freeze/thaw cycles, and hemolyzed specimens will be rejected. This test is a reflex from Drug Screen 9 Panel, Serum or Plasma (DRGSC9). This test is New York DOH approved.
Clinical Info
Used to monitor patient adherence. The absence of expected drug(s) and/or drug metabolite(s) may indicate non-compliance, inappropriate timing of specimen collection relative to drug administration, poor drug absorption, or limitations of testing. The concentration value must be greater than or equal to the cutoff to be reported as positive.
Clinical Limitation
For medical purposes only; not valid for forensic use.