Leukotriene E4, Urine 24 Hour
Test Mnemonic
ULTE4
CPT Codes
- 82542 - QTY (1)
LOINC ®
Not available
Includes
- Leukotriene E4, Ur
- Creatinine Conc
- Creatinine, 24 Hr, Ur
Performing Laboratory
Mayo Clinic Dpt of Lab Med & Pathology
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 5 mL | Urine, 24-hour (well-mixed) | Clean container (No preservatives) | Refrigerate during collection. | Frozen | Start collection within a few hours of symptom onset and collect urine for 24 hours. Specimen volume and 24-Hour Urine collection duration are required. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 24 hours |
| Refrigerated | 7 days |
| Frozen | 28 days |
Days Performed
Tue, Fri
Turnaround Time
3 - 7 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) | |
| Colorimetric Enzyme Assay |
Reference Range
| Leukotriene E4, Ur | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| < or = 104 pg/mg creatinine |
Special Info
Start collection within a few hours of symptom onset and collect urine for 24 hours. Specimen volume and 24-Hour Urine collection duration are required. This test is New York DOH approved.
Clinical Info
An aid to evaluate patients suspected of having systemic mastocytosis. CAUTIONS: Patients taking 5-lipoxygenase inhibitor Zileuton/Zyflo may have decreased concentrations of leukotriene E4 (LTE4) if dosage has not been discontinued for 48 hours. Systemic mastocytosis is a heterogenous disease and lack of elevated LTE4 does not exclude the diagnosis of mast cell disease. Increased excretion of LTE4 has also been reported in the following conditions: asthma, eosinophilic pneumonia, respiratory syncytial virus infection, atopic dermatitis, Crohn disease, and rheumatoid arthritis. This assay measures both LTE4 and the 11-trans-LTE4 as markers of mast cell release.