Hydroxylase-21 Antibody
Test Mnemonic
21OHAB
CPT Codes
- 83516 - QTY (1)
Aliases
- 21 Hydroxylase Antibody
- 21-Hydroxylase Autoantibodies, Serum
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | Gold SST | Refrigerated | Transfer 1 mL serum to standard aliquot tube. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Refrigerated | Transfer 1 mL serum to standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.3 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | After separation from cells: 1 week |
| Frozen | After separation from cells: 1 month |
| Ambient | After separation from cells: 24 hours |
Days Performed
Tue, Fri
Turnaround Time
3 - 8 days
Methodology
| Name | Description |
|---|---|
| Qualitative Enzyme-linked Immunosorbent Assay |
Reference Range
Special Info
Grossly hemolyzed or lipemic specimens are unacceptable. This test is New York DOH approved.
Clinical Info
This assay is intended for the qualitative determination of antibodies to steroid 21-hydroxylase in human serum. A positive result is indicative of primary adrenal insufficiency (Addison's disease). Results should be interpreted within the context of clinical symptoms, including functional adrenal testing. In males with adrenal insufficiency and negative results for 21-hydroxylase antibodies, X-Linked Adrenoleukodystrophy (X-ALD) should be excluded by using Very Long-Chain and Branched-Chain Fatty Acids Profile (FATLON) in plasma for screening.