HLA-B*15:02
Test Mnemonic
B1502
CPT Codes
- 81381 - QTY (1)
Aliases
- HLA-B*15:02 Genotyping
Performing Laboratory
Allogen Laboratories
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 5 mL | Whole blood | EDTA (Lavender) | Ambient | Send specimen in original tube. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 7 mL | Whole blood | ACD A or B (Yellow) | Ambient |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 1 week |
| Frozen | Unacceptable |
| Refrigerated | 1 week |
Days Performed
Mon - Fri
Turnaround Time
6 - 8 days
Methodology
| Name | Description |
|---|---|
| Polymerase Chain Reaction (PCR) | |
| Polymerase Chain reaction(PCR)/Sequence Specific Oligo Probes(SSO) | |
| Sequence based typing, PCR |
Reference Range
| HLA B*1502 Interp | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Refer to Report |
Special Info
Identifying individuals of Asian ancestry who are at risk of developing Stevens-Johnson syndrome and toxic epidermal necrolysis when administered carbamazepine, phenytoin, or fosphenytoin therapy
Clinical Info
The allele HLA-B*15:02 is associated with increased risk of developing severe skin reactions (Stevens-Johnson Syndrome and toxic epidermal necrolysis) in individuals of Asian ancestry when treated with Carbamazepine. Treatment with Carbamazepine in subjects positive for HLA-B*15:02 should be avoided. A negative result for HLA-B*15:02 does not rule out the possibility of such reactions. Therapy should be discontinued immediately and permanently should TEN or SJS develop. The FDA recommends that individuals of Asian ancestry be genotyped for the presence of the HLA-B*15:02 allele prior to receiving: -Carbamazepine, a drug used to treat epilepsy, manic/bipolar disorders, and neuropathic pain -Phenytoin and its soluble precursor fosphenytoin, drugs used to control seizures Some studies have also suggested a connection between HLA-B*15:02 positivity and adverse reactions to lamotrigine used for treating epilepsy and bipolar disorder.
Clinical Reference
Positive/Negative