Granulocyte Antibodies
Test Mnemonic
NEUTR
CPT Codes
- 86021 - QTY (1)
Aliases
- Anti-Neutrophil Antibody
- Neutrophil Antibody
- Neutrophil-Associated Antibodies
Performing Laboratory
ARUP
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Serum | No additive (Red) | Frozen | Remove serum from cells ASAP or within 2 hours of collection. Transfer serum to standard aliquot tube and freeze. Ship frozen on dry ice. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Serum | SST (Gold) | Frozen | Remove serum from cells ASAP or within 2 hours of collection. Transfer serum to standard aliquot tube and freeze. Ship frozen on dry ice. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: Unacceptable |
| Refrigerated | After separation from cells: Unacceptable |
| Frozen | After separation from cells: 1 month |
Days Performed
Mon, Thu
Turnaround Time
2 - 6 days
Reference Range
Special Info
This test is New York DOH approved. Ship frozen on dry ice.
Clinical Info
Neutrophil-associated antibodies may cause neutropenia in various autoimmune disorders including Felty syndrome, SLE and drug-induced neutropenia. Febrile transfusion reactions and isoimmune neonatal neutropenia may also be caused by antibodies to neutrophil-specific antigens or HLA antigens. A positive result on this test is not definitive for specific anti-neutrophil antibodies, since anti-HLA antibodies and immune complexes may also cause a positive result. The results of this test should be correlated to clinical history and other data. Circulating antibodies in patient's serum are measured by flow cytometry after incubation with normal neutrophils. Values greater than 2 standard deviations of a normal control population are interpreted as "weakly positive" and greater than 3 standard deviations as "positive."