FISH for TP63 and DUSP22-IRF4 Panel
Test Mnemonic
TPDUFP
CPT Codes
- 88377 - QTY (2)
Includes
- LSI 6p25.3
- LSI 3q28
Performing Laboratory
Cleveland Clinic Laboratories
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4 slides | Paraffin block, formalin fixed | Slides, unstained | Ambient | Ambient | Pre and Post H&E with four unstained slides with defined marked areas for analysis |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 4 slides | Pre and Post H&E with four unstained slides with defined marked areas for analysis |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | FFPE slides at room temperature |
Days Performed
5 days per week
Turnaround Time
3 - 5 days
Methodology
| Name | Description |
|---|---|
| Fluorescent In-Situ Hybridization (FISH) |
Clinical Info
Interphase FISH analysis utilizing dual color, break-apart probe sets for the DUSP22/IRF genes at 6p25.3 and the TP63 gene at 3q28. Rearrangements of these genes may be observed in ALK-negative, anaplastic large cell lymphoma. The translocation partner gene cannot be identified in this assay. If no cells are available for analysis, no analysis charges will be incurred.