FISH for Angiosarcoma MYC Amplification
Test Mnemonic
MYCAMP
CPT Codes
- 88377 - QTY (1)
Aliases
- MYCAMP
Includes
- LSI 14q32
- LSI 8q24
Performing Laboratory
Cleveland Clinic Laboratories
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 slides | Slide (s), unstained | Ambient | Ambient | One formalin-fixed, paraffin embedded block containing representative tissue OR unstained 4 μm tissue sections on electrostatically charged slides containing representative tumor. Tissue must be fixed in formalin NOT B5 or PREFER fixative |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Sample is formalin fixed and must not be fixed in Prefer or B5. |
Days Performed
5 days per week
Turnaround Time
5 - 7 days
Methodology
| Name | Description |
|---|---|
| Fluorescent In-Situ Hybridization (FISH) |
Clinical Info
Interphase FISH analysis utilizing an enumeration probe specific to the MCY gene at 8q24.1, in association with the IGH gene at 14q32.33. Used in the differentiation of cutaneous angiosarcomas from atypical vascular lesions after radiotherapy, as well as the diagnosis of primary cutaneous angiosarcoma. If no cells are available for analysis, no analysis chares will be incurred.