Drug Detection Panel, TOF-MS, Umbilical Cord Tissue
Test Mnemonic
DRGTOF
CPT Codes
- 80346/G0480 - QTY (1)
- 80348/G0480 - QTY (1)
- 80353/G0480 - QTY (1)
- 80361/G0480 - QTY (1)
- 80356/G0480 - QTY (1)
- 80365/G0480 - QTY (1)
- 80373/G0480 - QTY (1)
- 80354/G0480 - QTY (1)
- 80363/G0480 - QTY (1)
- 80355/G0480 - QTY (1)
- 80359/G0480 - QTY (1)
- 80325/G0480 - QTY (1)
- 80345/G0480 - QTY (1)
- 80372/G0480 - QTY (1)
- 80358/G0480 - QTY (1)
- 83992/G0480 - QTY (1)
- 80368/G0480 - QTY (1)
Includes
- Buprenorphine
- Norbuprenorphine
- Codeine
- Dihydrocodeine
- Fentanyl
- Hydrocodone
- Norhydrocodone
- Hydromorphone
- Meperidine
- Methadone
- Methadone metabolite
- 6-Acetylmorphine
- Morphine
- Naloxone
- Oxycodone
- Noroxycodone
- Oxymorphone
- Noroxymorphone
- Propoxyphene
- Tapentadol
- Tramadol
- N-desmethyltramadol
- O-desmethyltramadol
- Amphetamine
- Benzoylecgonine
- m-OH-Benzoylecgonine
- Cocaethylene
- Cocaine
- MDMA-Ecstasy
- Methamphetamine
- Phentermine
- Alprazolam
- Alpha-OH-Alprazolam
- Butalbital
- Clonazepam
- 7-Aminoclonazepam
- Diazepam
- Lorazepam
- Midazolam
- Alpha-OH-Midazolam
- Nordiazepam
- Oxazepam
- Phenobarbital
- Temazepam
- Zolpidem
- Phencyclidine - PCP
- Gabapentin
Performing Laboratory
ARUP
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| Other | Clean container | Refrigerated | At least 8 inches of umbilical cord (approximately the width of a sheet of paper). Drain and discard any blood. Rinse the exterior of the cord segment with normal saline or water. Pat the cord dry and transport at least 8 inches of umbilical cord in a routine urine collection cup or use the Security Kit for Meconium/Umbilical Drug Detection (ARUP supply #51548). |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| N/A | 6 inches (Absolute minimum) |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | 3 weeks |
| Frozen | 1 year |
| Ambient | 1 week |
Days Performed
Sun - Sat
Turnaround Time
2 - 4 days
Methodology
| Name | Description |
|---|---|
| Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) |
Reference Range
| 6-Acetylmorphine | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| 7-Aminoclonazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Alpha-OH-Alprazolam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 0.5 ng/g | |||||
| Alpha-OH-Midazolam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 2 ng/g | |||||
| Alprazolam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 0.5 ng/g | |||||
| Amphetamine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 5 ng/g | |||||
| Benzoylecgonine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Buprenorphine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Butalbital | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 25 ng/g | |||||
| Clonazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Cocaethylene | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Cocaine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Codeine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 0.5 ng/g | |||||
| Diazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Dihydrocodeine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| EDDP | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Gabapentin | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 10 ng/g | |||||
| Hydrocodone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 0.5 ng/g | |||||
| Hydromorphone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 0.5 ng/g | |||||
| Lorazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 5 ng/g | |||||
| MDMA- Ecstasy | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 5 ng/g | |||||
| Meperidine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 2 ng/g | |||||
| Methadone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 2 ng/g | |||||
| Methamphetamine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 5 ng/g | |||||
| Midazolam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| m-OH-Benzoylecgonine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Morphine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 0.5 ng/g | |||||
| Naloxone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| N-desmethyltramadol | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 2 ng/g | |||||
| Norbuprenorphine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | cutoff 0.5 ng/g | ||||
| Nordiazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Norhydrocodone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | cutoff 1 ng/g | ||||
| Noroxycodone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | cutoff 1 ng/g | ||||
| Noroxymorphone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 0.5 ng/g | |||||
| O-desmethyltramadol | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 2 ng/g | |||||
| Oxazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 2 ng/g | |||||
| Oxycodone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 0.5 ng/g | |||||
| Oxymorphone | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 0.5 ng/g | |||||
| Phencyclidine-PCP | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Phenobarbital | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 75 ng/g | |||||
| Phentermine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 8 ng/g | |||||
| Propoxyphene | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Tapentadol | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 2 ng/g | |||||
| Temazepam | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 1 ng/g | |||||
| Tramadol | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 2 ng/g | |||||
| Zolpidem | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| cutoff 0.5 ng/g |
Special Info
Cords soaking in blood or other fluids are unacceptable. Formalin-fixed specimens or tissue that is obviously decomposed will not be accepted. This test is New York DOH approved.
Clinical Info
Detection of drugs in umbilical cord tissue is intended to reflect maternal drug use during approximately the last trimester of a full-term pregnancy. The pattern and frequency of drug(s) used by the mother cannot be determined by this test. A negative result does not exclude the possibility that a mother used drugs during pregnancy. Detection of drugs in umbilical cord tissue depends on extent of maternal drug use, as well as drug stability, unique characteristics of drug deposition in umbilical cord tissue, and the performance of the analytical method. Drugs administered during labor and delivery may be detected. Detection of drugs in umbilical cord tissue does not insinuate impairment and may not affect outcomes for the infant. Interpretive questions should be directed to the laboratory.