Cytomegalovirus Antiviral Drug Resistance by Sequencing
Test Mnemonic
CYTSEQ
CPT Codes
- 87910 - QTY (1)
- 87900 - QTY (1)
Aliases
- CMV Foscarnet Resistance
- CMV Resistance Genotype
- CMV Letermovir Resistance
- CMV Maribavir Resistance
- CMV UL27
- CMV UL56
- CMV UL54
- CMV UL97
- CMV Cidofovir Resistance
- CMV Ganciclovir Resistance
Includes
- CMV Drug Resistance by NGS, 5 Drugs (Ganciclovir, Foscarnet, Cidofovir, Maribavir, Letermovir)
Performing Laboratory
ARUP
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Plasma | EDTA (Lavender) | Frozen | Draw 2 tubes to ensure adequate volume. Separate plasma from cells within 8 hours of collection. Transfer 3 mL plasma into a standard aliquot tube. Submit most recent viral load and test date, if available. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Plasma | EDTA PPT (White) | Frozen | Draw 2 tubes to ensure adequate volume. Separate plasma from cells within 8 hours of collection. Transfer 3 mL plasma into a standard aliquot tube. Submit most recent viral load and test date, if available. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Frozen | After separation from cells: 1 month |
| Refrigerated | After separation from cells: 72 hours |
| Ambient | After separation from cells: 8 hours |
Days Performed
Sun - Sat
Turnaround Time
4 - 10 days
Methodology
| Name | Description |
|---|---|
| Massive Parallel Sequencing |
Special Info
Please submit most recent viral load and test date, if available. Heparinized specimens and serum are unacceptable.
Clinical Info
Provides antiviral susceptibility information for ganciclovir, foscarnet, cidofovir, maribavir, and letermovir. Intended for patients with viral load >2.6 log IU/mL.
Clinical Limitation
This test may be unsuccessful if the plasma CMV DNA viral load is less than 2.6 log IU/mL.