Clozapine
Test Mnemonic
CLOZA
CPT Codes
- 80159 - QTY (1)
Performing Laboratory
Cleveland Clinic Laboratories
FDA Category
In Vitro Diagnostic
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | Red Plain | See note | Refrigerated | Centrifuge and aliquot within 2 hours of collection. Refrigerate serum aliquot. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 7 days |
| Refrigerated | 21 days |
| Frozen | 21 days |
Days Performed
6 days per week
Turnaround Time
1 - 4 days
Methodology
| Name | Description |
|---|---|
| Turbidimetric Immunoassay (TUI) |
Reference Range
| Clozapine | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 350 - 600 | ng/mL | Urgent | > 1000 | ng/mL |
Special Info
Timing of specimen collection: Pre-dose (trough) draw - At steady state concentration. Do not collect in a gel separator tube. Centrifuge and transfer serum to a CCL tube and refrigerate within 2 hours of collection.
Clinical Info
Normal reference range is based on therapeutic range.
Clinical Limitation
The clinical context should be taken into consideration when interpreting Clozapine results. Assess dose-related side effects and clinical evidence of toxicity if a Clozapine concentration is higher than expected. Poor adherence, drug interactions, or changes in smoking status may be relevant when Clozapine concentrations are lower than expected.