Aquaporin-4 Receptor Antibody, IgG by CBA-IFA, CSF with Reflex to Titer
Test Mnemonic
AQPCSF
CPT Codes
- 86052 - QTY (1)
Aliases
- Neuromyelitis Optica (NMO), CSF
Includes
- Neuromyelitis Optica/AQP4-IgG, CSF
Performing Laboratory
ARUP
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL | Cerebrospinal fluid (CSF) | Clean container | Refrigerated | Transfer 0.5 mL CSF to standard aliquot tube |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.15 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Refrigerated | 2 weeks |
| Frozen | 1 year |
| Ambient | 48 hours |
Days Performed
Mon, Wed, Fri
Turnaround Time
2 - 7 days
Methodology
| Name | Description |
|---|---|
| Semi-Quantitative Cell-Based Indirect Fluorescent Antibody |
Reference Range
Special Info
If AQP4 antibody IgG is positive, then an AQP4 antibody IgG titer is reported. Additional charges apply. Hemolyzed, contaminated specimens or severely lipemic specimens are unacceptable. This test is New York DOH approved.
Clinical Info
This test is useful in the initial evaluation of neuromyelitis optica (NMO) spectrum disorders. NMO commonly presents with optic neuritis or longitudinally extensive transverse myelitis. Approximately 75% percent of patients with NMO have antibodies to the aquaporin-4 (AQP4) receptor. While the absence of AQP4 receptor antibodies does not rule out a diagnosis of NMO, presence of this antibody is diagnostic for NMO.