Anti-HMGCR Antibody, IgG
Test Mnemonic
HMGCR
CPT Codes
- 83516 - QTY (1)
LOINC ®
Not available
Aliases
- HMGCR Autoantibodies
- HMG CoA Reductase Antibodies
- 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase
Includes
- HMGCR Antibody, IgG
Performing Laboratory
ARUP
FDA Category
Analyte Specific Reagent
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL | Serum | SST (Gold) | Refrigerated | Separate serum from cells ASAP or within 2 hours of collection and transfer to standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.3 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 48 hours |
| Refrigerated | After separation from cells: 2 weeks |
| Frozen | After separation from cells: 1 year (Avoid repeated freeze/thaw cycles) |
Days Performed
Fri
Turnaround Time
2 - 16 days
Methodology
| Name | Description |
|---|---|
| Semi Quantitative Enzyme Linked Immunosorbent Assay |
Reference Range
| Anti HMGCR Ab Test | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| 0-19 Units: Negative |
Special Info
Contaminated, or severely hemolyzed, icteric, or lipemic specimens will be rejected. This test is New York state approved.
Clinical Info
Useful for differential diagnosis of myositis in patients with or without statin exposure. IgG antibodies to 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) are mainly associated with necrotizing autoimmune myopathy (NAM) in a subset of statin-treated patients. Although infrequent, these antibodies may also be observed in statin-naive patients with NAM. Strong clinical correlation is recommended in the absence of muscle fiber necrosis, elevated serum creatine kinase, perimysial pathology, and/or statin exposure.