Special Communication
Changes to NCYTO, URCAT2, MYOSPL, RUFIN, LIVFIB, & AJPWO Testing
Changes to Reference Ranges
Effective August 19, 2019.
Anti-Neut Cyto Ab with Reflex to Titer and MPO/PR3 Ab (NCYTO)
Charting Name Change
Serine Protease 3, IgG will change to Serine Proteinase 3, IgG.
Effective August 19, 2019.
Catecholamines Fractionated by LC-MS/MS, Urine Free (URCAT2)
Reference Ranges: Epinephrine, Urine per 24h
0 – 3 Years:
Not Established
4 – 10 Years:
1 – 14 µg/d
11 – 17 Years:
1 – 18 µg/d
18 – 99 Years:
1 – 14 µg/d
Effective August 19, 2019.
Polymyositis and Dermatomyositis Panel (MYOSPL)
Reference Ranges:
Jo-1 Antibody, IgG
Negative:
29 AU/mL or less
Equivocal:
30 – 40 AU/mL
Positive:
41 AU/mL or greater
PL-7 (threonyl-tRNA synthetase) Antibody:
Negative
PL-12 (alanyl-tRNA synthetase) Antibody:
Negative
EJ (glycyl-tRNA synthetase) Antibody:
Negative
SRP (Signal Recognition Particle) Ab:
Negative
OJ (isoleucyl-tRNA synthetase) Antibody:
Negative
Mi-2 (nuclear helicase protein) Antibody:
Negative
P155/140 Antibody:
Negative
SAE1 (SUMO activating enzyme) Antibody:
Negative
MDA5 (CADM-140) Antibody:
Negative
NXP-2 (Nuclear matrix protein-2) Antibody:
Negative
TIF-1 gamma (155 kDa) Antibody:
Negative
Effective August 19, 2019.
Rufinamide (RUFIN)
Reference Ranges:
Therapeutic Range:
5 – 30 µg/mL
Dose-Related Range (values at dosages of 800 – 7200 mg/day):
3 – 30 µg/mL
Effective September 23, 2019.
Liver Fibrosis, FibroTest-ActiTest (LIVFIB)
Reference Ranges: Fibrosis Interpretation
No fibrosis
FibroTest Score: ≥ 0 and ≤ 0.21
Metavir Score: F0
No fibrosis
FibroTest Score: > 0.21 and ≤ 0.27
Metavir Score: F0 – F1
Minimal fibrosis
FibroTest Score: > 0.27 and ≤ 0.31
Metavir Score: F1
Minimal fibrosis
FibroTest Score: > 0.31 and ≤ 0.48
Metavir Score: F1 – F2
Moderate fibrosis
FibroTest Score: > 0.48 and ≤ 0.58
Metavir Score: F2
Advanced fibrosis
FibroTest Score: > 0.58 and ≤ 0.72
Metavir Score: F3
Advanced fibrosis
FibroTest Score: > 0.72 and ≤ 0.74
Metavir Score: F3 – F4
Severe fibrosis
FibroTest Score: > 0.74 and ≤ 1.00
Metavir Score: F4
Reference Ranges: Necroinflammatory Activity Interpretation
No activity
ActiTest Score: ≥ 0 and ≤ 0.17
Metavir Score: A0
No activity
ActiTest Score: > 0.17 and ≤ 0.29
Metavir Score: A0 – A1
Minimal activity
ActiTest Score: > 0.29 and ≤ 0.36
Metavir Score: A1
Minimal activity
ActiTest Score: > 0.36 and ≤ 0.52
Metavir Score: A1 – A2
Significant activity
ActiTest Score: > 0.52 and ≤ 0.60
Metavir Score: A2
Significant activity
ActiTest Score: > 0.60 and ≤ 0.62
Metavir Score: A2 – A3
Severe activity
ActiTest Score: > 0.62 and ≤ 1.00
Metavir Score: A3
Changes to Test Build
Ashkenazi Jewish Diseases (AJPWO)
Effective August 19, 2019.
Interfaced Clients: These updates may require changes to the Test Build.
Any additional information will be included in a future Technical Update. If you have any questions about these changes, please contact Client Services for assistance.