Products of Conception Chromosome Analysis with Reflex SNP Array
Test Mnemonic
POCHF
CPT Codes
- 88233 - QTY (1)
- 88262 - QTY (1)
- 81229 - QTY (1)
Aliases
- Chromosome Analysis
- Products of Conception
- SNP Array
Performing Laboratory
Cleveland Clinic Laboratories
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 10 mm square | Products of conception (POC) | Sterile container | Ambient | Ambient | Fresh tissue sample from the fetus, placenta, umbilical cord, amniotic membrane and chorionic membrane are accepted. Do not expose to formalin or other fixatives. Do not freeze. Place specimen in a sterile container containing RPMI, Hank's solution or sterile saline. Keep at room temperature; may refrigerate if specimen must be held overnight. Transport to the laboratory as soon as possible to ensure cell viability. |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Preferred |
| Refrigerated | Acceptable |
| Frozen | Unacceptable |
Days Performed
7 days a week
Turnaround Time
28 - 30 days
Methodology
| Name | Description |
|---|---|
| Comparative genomic hybridization-oligo based | |
| Culture Karyotyping Microscopy |
Special Info
Upon receipt in the lab, a tissue sample will be frozen. In the event of cell culture failure, this sample will be used to isolate DNA and perform chromosomal oligonucleotide and SNP based microarray. Long-standing fetal demise, delayed specimen transport and improper handling can increase the risk of tissue culture failure, which leads to no chromosome result. Upon receipt in the lab, a tissue sample will be frozen. In the event of cell culture failure, this sample will be used to isolate DNA and perform chromosomal oligonucleotide and SNP based microarray. If chromosome analysis/karyotype cannot be performed due to cell culture failure, there will be no charge for that test (CPT codes 88233, 88262, 88291). Instead, there will be charge for microarray (CPT code 81229).
Clinical Info
Evaluate the cause of miscarriage.