Direct Renin
Test Mnemonic
RENIND
CPT Codes
- 84244 - QTY (1)
LOINC ®
2915-7
Performing Laboratory
Cleveland Clinic Laboratories
FDA Category
In Vitro Diagnostic
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | EDTA (Lavender) | Ambient | Frozen, Critical | Centrifuge and remove plasma from cells within 4 hours of collection. Freeze plasma immediately after separation from cells. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Frozen | 30 days |
| Ambient | Unacceptable |
| Refrigerated | Unacceptable |
Days Performed
Mon - Fri
Turnaround Time
2 - 7 days
Methodology
| Name | Description |
|---|---|
| Chemiluminescence Immunoassay (CLIA) |
Reference Range
| Direct Renin | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 40 Years | Normal | Upright: 4.2-52.2 | pg/mL | 41 Years | 99 Years | Normal | Upright: 3.6-81.6 | pg/mL | Years | 40 Years | Normal | Supine: 3.2-33.2 | pg/mL | 41 Years | 99 Years | Normal | Supine: 2.5-45.1 | pg/mL |
Special Info
Fasting specimens are recommended but not required. Record the time of day and patient's posture during blood collection (supine or upright). DO NOT pre-chill collection tubes, store tubes on ice or refrigerate; cryoactivation of prorenin occurs when samples are refrigerated. Biotin levels of up to 100mg/day have not shown interference with this assay. Patients taking >100 mg/day to 300 mg/day should refrain from taking Biotin for 1 hour prior to sample collection. Patients taking a Biotin dose >300 mg/day should consult with their physician or the laboratory prior to having a sample taken. Clinicians should consider biotin interference as a source of error, when clinically suspicious of the laboratory result.
Clinical Info
Diagnosis of disorders of the renin-angiotensin-aldosterone system (RAAS). Aids in diagnosis of certain types of hypertension.
Clinical Limitation
Criteria for Rejection: Refrigerated, grossly hemolyzed, grossly lipemic, and obviously microbially contaminated samples will be rejected.