Catecholamines Fractionated by LC-MS/MS, Urine Free

Catecholamines Fractionated by LC-MS/MS, Urine Free Print

Test Mnemonic

URCAT2

CPT Codes

82384 - QTY (1)

Aliases

Adrenaline
Dopamine, Random
Epinephrine, Random
Fractionation, Catecholamines
Free Catecholamine Fractionation
Noradrenaline
Norepinephrine, Random
Catecholamines, 24-hour or random urine

Includes

Creatinine, Urine - per volume
Creatinine, Urine - per 24h
Epinephrine, Urine - per 24h
Epinephrine, Urine - ratio to CRT
Epinephrine, Urine - per volume
Norepinephrine, Urine - per 24h
Norepinephrine, Urine - ratio to CRT
Norepinephrine, Urine - per volume
Dopamine, Urine - per 24h
Dopamine, Urine - ratio to CRT
Dopamine, Urine - per volume
Catecholamines, Urine Interpretation

Performing Laboratory

ARUP

FDA Category

Laboratory Developed Test

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
4 mL	Urine, 24-hour (well-mixed)	24 HR Urine Container	Refrigerate during collection.	Refrigerated	Drugs and medications may affect results and should be discontinued for at least 72 hours prior to specimen collection. pH urine to > 2 and < 7 with 6M HCl acid or sulfamic acid before transport. Record total volume and collection time interval on sample and test request form.

Alternate Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
4 mL	Urine, random	Clean container		Refrigerated	Drugs and medications may affect results and should be discontinued for at least 72 hours prior to specimen collection. pH urine to > 2 and < 7 with 6M HCl acid or sulfamic acid before transport. Record volume on sample and test request form.

Minimum Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
2.5 mL

Stability

Environmental Condition	Description
Refrigerated	1 week (unpreserved); 1 month (preserved)
Frozen	Unacceptable (unpreserved); 6 months (preserved)
Ambient	Unacceptable

Days Performed

Sun - Sat

Turnaround Time

2 - 6 days

Methodology

Name	Description
High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)

Reference Range

Creatinine, Urine 24h
Sex	Age From	Age To	Type	Range	Range Unit
Male	3 Years	8 Years	Normal	140-700	mg/d
Male	9 Years	12 Years	Normal	300-1300	mg/d
Male	13 Years	17 Years	Normal	500-2300	mg/d
Male	18 Years	50 Years	Normal	1000-2500	mg/d
Male	51 Years	80 Years	Normal	800-2100	mg/d
Male	81 Years	99 Years	Normal	600-2000	mg/d
Female	3 Years	8 Years	Normal	140-700	mg/d
Female	9 Years	12 Years	Normal	300-1300	mg/d
Female	13 Years	17 Years	Normal	400-1600	mg/d
Female	18 Years	50 Years	Normal	700-1600	mg/d
Female	51 Years	80 Years	Normal	500-1400	mg/d
Female	81 Years	99 Years	Normal	400-1300	mg/d
Dopamine, Ur ratio to CRT
Sex	Age From	Age To	Type	Range	Range Unit
	Months	11 Months	Normal	240-1290	ug/g crt
	1 Years	3 Years	Normal	80-1220	ug/g crt
	4 Years	10 Years	Normal	220-720	ug/g crt
	11 Years	17 Years	Normal	120-450	ug/g crt
	18 Years	99 Years	Normal	0-250	ug/g crt
Dopamine, Urine 24 h
Sex	Age From	Age To	Type	Range	Range Unit
	Years	3 Years	Normal	Not Established	.
	4 Years	10 Years	Normal	80-440	ug/d
	11 Years	17 Years	Normal	100-496	ug/d
	18 Years	99 Years	Normal	71-485	ug/d
Epinephrine, Ur ratio to CRT
Sex	Age From	Age To	Type	Range	Range Unit
	Months	11 Months	Normal	0-380	ug/g crt
	1 Years	3 Years	Normal	0-82	ug/g crt
	4 Years	10 Years	Normal	5-93	ug/g crt
	11 Years	17 Years	Normal	3-58	ug/g crt
	18 Years	99 Years	Normal	0-20	ug/g crt
Epinephrine, Urine per 24h
Sex	Age From	Age To	Type	Range	Range Unit
	Years	3 Years	Normal	Not Established
	4 Years	10 Years	Normal	1-14	ug/d
	11 Years	17 Years	Normal	1-18	ug/d
	18 Years	99 Years	Normal	1-14	ug/d
Norepinephrine, Ur ratio to CRT
Sex	Age From	Age To	Type	Range	Range Unit
	Months	11 Months	Normal	25-310	ug/g crt
	1 Years	3 Years	Normal	25-290	ug/g crt
	4 Years	10 Years	Normal	27-110	ug/g crt
	11 Years	17 Years	Normal	4-105	ug/g crt
	18 Years	99 Years	Normal	0-45	ug/g crt
Norepinephrine, Urine 24h
Sex	Age From	Age To	Type	Range	Range Unit
	Years	3 Years	Normal	Not Established	.
	4 Years	10 Years	Normal	7-65	ug/d
	11 Years	17 Years	Normal	12-96	ug/d
	18 Years	99 Years	Normal	14-120	ug/d

Special Info

Drugs and medications may affect results and should be discontinued for at least 72 hours prior to specimen collection, if possible. Catecholamines are not stable above pH 7. The pH of such specimens must be adjusted by the addition of 6M HCl acid or sulfamic acid prior to transport. A pH less than 2 can cause assay interference. Record total volume and collection time interval on transport tube and test request form. Specimen preservation Option 1: Transfer a 4 mL aliquot (Min: 2.5 mL) to an ARUP Standard Transport Tube. Adjust pH to 2.0-4.0 with 6M HCl. Specimen Preservation Option 2: Transfer a 4 mL aliquot (Min: 2.5 mL) to an ARUP Standard Transport Tube containing 20 mg sulfamic acid (ARUP Supply #48098), available by contacting Client Services at 800.628.6816 or 216.444.5755 (Min: 2.5 mL). Room temperature specimens, specimens preserved with boric acid or acetic acid, or specimens with pH > 7 will be rejected. This test is New York DOH approved.

Clinical Info

This test is useful to evaluate clinical symptoms of excess catecholamine secretion. Not recommended for evaluation of paraganglioma or pheochromocytoma. The optimal specimen for this testing is a 24-hour urine collection.