Plasminogen Activator Inhibitor Antigen
Test Mnemonic
PAI1M
CPT Codes
- 85415 - QTY (1)
Performing Laboratory
Mayo Clinic Dpt of Lab Med & Pathology
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Plasma | Sodium citrate (Lt. Blue) | Frozen | Spin down, remove plasma, and spin again. Freeze double-centrifuged platelet poor plasma immediately at < or = -40 degrees C. Each coagulation test should have its own vial. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Frozen | 2 years |
Days Performed
Varies
Turnaround Time
5 - 9 days
Methodology
| Name | Description |
|---|---|
| Enzyme-Linked Immunosorbent Assay (ELISA) |
Reference Range
| PAI-1 Ag,P | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | 3.0 - 72.0 | ng/mL |
Special Info
Spin down, remove plasma, and spin again. Freeze double-centrifuged platelet poor plasma immediately at < or = -40 degrees C. Each coagulation test should have its own vial.
Clinical Info
The plasminogen activator inhibitor type 1 (PAI-1) level shows a diurnal variation with the highest levels occurring in the morning. The PAI-1 level increases during pregnancy and decreases rapidly after delivery. The extremely rare presence of antimouse antibodies in certain patients may lead to anomalous results. Inappropriate specimen collection and processing may lead to platelet activation and release of platelet PAI-1. Consequently, care must be taken to remove all platelets and minimize platelet activation during specimen collection and processing.