Dabigatran Assay
Test Mnemonic
DBGTRN
CPT Codes
- 80299 - QTY (1)
LOINC ®
68980-2
Aliases
- Pradaxa
Performing Laboratory
Cleveland Clinic Laboratories
FDA Category
Research Use Only
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Plasma | Sodium citrate (Lt. Blue) | Frozen |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 4 hours |
| Refrigerated | Unacceptable |
| Frozen | 4 weeks |
Days Performed
Sun - Sat
Turnaround Time
4 hours
Methodology
| Name | Description |
|---|---|
| Chromogenic |
Reference Range
| Dabigatran | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Dose and Regimen: 150 mg bid; Peak: 175 (117 - 275) ng/mL | Dose and Regimen: 150 mg bid; Trough: 91 (61 - 143) ng/mL |
Special Info
Peak: 2 hours after dose; Trough: 12 hours after dose
Clinical Info
Dabigatran etexilate is a novel, orally administered direct thrombin inhibitor. It has proved effective for treating and preventing venous thromboembolism, preventing stroke in patients with atrial fibrillation, and treating myocardial infarct. It can be used to prevent hemorrhagic and thromboembolic complications associated with long term anticoagulation with warfarin. As an active form, dabigatran is a potent, competitive and reversible direct inhibitor of the active site of thrombin with a half life of approximately 12 hours. Dabigatran will be measured by chromogenic anti-IIa assay using specific Aniara Dabigatran calibrator performed on the STA-R Evolution coagulometer.