Cryoglobulin, Qual w Reflex to IgG, IgA, IgM
Test Mnemonic
CRYQL
CPT Codes
- 82595 - QTY (1)
Includes
- Cryoglobulin, Qualitative
Performing Laboratory
ARUP
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL | Serum | No additive (Red) | Ambient | Fasting for a minimum of 8 hours is required. Do not use serum separator tubes. Collect in a pre-warmed (37C), no additive (Red) tube. Immediately after collection, place tube in heel warmer or 37°C (warm, not hot) water. Keep sample warm at 37C until clotting is complete (up to 1 hour). Separate serum from cells and transfer to standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 1 week |
| Refrigerated | After separation from cells: 1 week |
| Frozen | After separation from cells: Uncacceptable |
Days Performed
Sun - Sat
Turnaround Time
4 - 6 days
Methodology
| Name | Description |
|---|---|
| Qualitative Cold Precipitation |
Reference Range
Special Info
The sample is examined daily for the presence of cryoglobulin. If after 3 days cryoprecipitate is observed, then quantitative immunoglobulins (IgG, IgA, IgM) will be added at an additional cost. Fasting for a minimum of 8 hours is required. Do not use serum separator tubes. Collect in a pre-warmed (37C), no additive (Red) tube. Immediately after collection, place tube in heel warmer or 37°C (warm, not hot) water. Keep sample warm at 37C until clotting is complete (up to 1 hour). Grossly hemolyzed or lipemic specimens will be rejected. This test is New York state approved.
Clinical Info
This test is useful in evaluation of patients with vasculitis, macroglobulinemia, or multiple myeloma in whom symptoms occur with exposure to cold.