Herpes Simplex IgM, Abs, with IgG Reflex
Test Mnemonic
HSVGM
CPT Codes
- 86695 if reflexed - QTY (1)
- 86696 if reflexed - QTY (1)
- 86694 - QTY (1)
Aliases
- HerpeSelect
- HSV Antibodies
Includes
- HSV IgG Type 1 Antibody
- HSV IgG Type 2 Antibody
- HSV IgM Types 1 and 2 (combined) Antibodies
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Refrigerated |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | No additive (Red) | Refrigerated |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.5 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 1 day |
| Refrigerated | 7 days |
| Frozen | 14 days |
Days Performed
Tue, Fri
Turnaround Time
1 - 4 days
Methodology
| Name | Description |
|---|---|
| Enzyme Immunoassay (EIA) | |
| Multiplex |
Reference Range
Special Info
FOR HSVM: Avoid using hemolyzed, lipemic, or bacterially contaminated sera. FOR HSVG12:Avoid hemolyzed samples. Avoid multiple freeze thaw cycles (3 is acceptable).
Clinical Info
HSV IgM testing will reflex HSV IgG 1 and 2 testing, followed by an overall HSV interpretation. HSV IgM test may only be considered where HSV PCR is negative but HSV infection is clinically suspected yet all other causes have already been ruled out. HSV IgM antibody test is used as an aid in diagnosis of primary HSV infection. The test may become positive during HSV reactivation. Clinical correlation is required. HSV IgG sero-conversion may take several weeks after a primary infection. Repeat testing maybe warranted if clinically indicated. Early institution of anti-virals may abrogate or delay humoral response. Please pay close attention to the overall HSV interpretation.
Clinical Limitation
Cannot exclude recent primary HSV infection if the specimen collected within 7-10 days after onset the of signs and symptoms. Non-specific reactivity is not uncommon with HSV IgM serology.