DNAse-B Antibody | Cleveland Clinic Laboratories

DNAse-B Antibody Print

Test Mnemonic

DASEAB

CPT Codes

86215 - QTY (1)

Aliases

ADNB

Performing Laboratory

ARUP

FDA Category

Laboratory Developed Test

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
1 mL	Serum	SST (Gold)		Refrigerated	Separate serum from cells ASAP or within 2 hours of collection and transfer to standard aliquot tube

Minimum Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
0.4 mL

Stability

Environmental Condition	Description
Ambient	After separation from cells: 2 hours
Refrigerated	After separation from cells: 8 days
Frozen	After separation from cells: 3 months

Days Performed

Sun - Sat

Turnaround Time

2 - 5 days

Methodology

Name	Description
Quantitative Nephelometry

Reference Range

DNAse B Ab
Sex	Age From	Age To	Type	Range	Range Unit
	Years	6 Years	Normal	< 250	U/mL
	7 Years	17 Years	Normal	< 310	U/mL
	18 Years	99 Years	Normal	< 260	U/mL

Special Info

Plasma or severely hemolyzed specimens are unacceptable. This test is New York DOH approved.

Clinical Info

This test is used to confirm current or recent infection with group A Streptococcus in patients suspected of having a nonsuppurative complication such as acute glomerulonephritis (AGN) or acute rheumatic fever (ARF). DNase-B Antibody and Streptolysin O Antibody (ASO) are generally ordered concurrently. Elevated titers of ASO indicate a recent group A Streptococcus infection. AntiDNase B antibodies typically remain elevated longer than ASO and may remain elevated for several months after infection. Patients suspected of having complications related to a recent Streptococcus infection such as AGN or ARF may have elevated anti-DNase B but normal ASO antibody titers. A negative or very low antiDNase B and ASO antibody titers, especially from a specimen tested 2 weeks after a suspected infection, indicates unlikely incidence of a recent Streptococcus infection.