Acetylcholine Receptor and Striated Muscle Antibodies Reflexive Panels, and Titin Antibody

Acetylcholine Receptor and Striated Muscle Antibodies Reflexive Panels, and Titin Antibody Print

Test Mnemonic

ACESTR

CPT Codes

83516 - QTY (1)
86255 - QTY (1)
86041 - QTY (1)
86042 - QTY (1)

Includes

Acetylcholine Receptor Blocking Antibody
Titin Antibody
Striated Muscle Antibody, IgG Screen
Striated Muscle Antibody, IgG Titer (if indicated)
Acetylcholine Binding Antibody

Performing Laboratory

ARUP

FDA Category

Laboratory Developed Test

Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
1.5 mL	Serum	SST (Gold)		Refrigerated	Separate serum from cells ASAP or within 1 hour of collection

Alternate Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
1.5 mL	Serum	No additive (Red)		Refrigerated	Separate serum from cells ASAP or within 1 hour of collection

Minimum Specimen Requirements

Volume	Type	Container	Collect Temperature	Transport Temperature	Special Instructions
0.7 mL

Stability

Environmental Condition	Description
Ambient	2 days
Refrigerated	2 weeks
Frozen	1 year

Days Performed

Mon - Fri

Turnaround Time

2 - 9 days

Methodology

Name	Description
Semi-Quantitative Indirect Fluorescent Antibody
Semi Quantitative Enzyme Linked Immunosorbent Assay
Semi-Quantiative Flow Cytometry
Quantitative Radioimmunoassay

Reference Range

Acetylcholine Binding Antibody
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	Negative: 0.0 - 0.4	nmol/L
	Years	99 Years	Normal	Positive: >= 0.5	nmol/L
Acetylcholine Blocking Antibody
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	Negative: 0 - 26	% Blocking
	Years	99 Years	Normal	Intermediate: 27 - 41	% Blocking
	Years	99 Years	Normal	Positive: >= 42	% Blocking
Striated Muscle Antibody, IgG Screen
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	< 1:40 No antibody detected	.
Titin Antibody
Sex	Age From	Age To	Type	Range	Range Unit
	Years	99 Years	Normal	Negative: 0.00 to 0.45	IV
	Years	99 Years	Normal	Intermediate: 0.46 - 0.71	IV
	Years	99 Years	Normal	Positive: >= 0.72	IV

Special Info

If Acetylcholine Receptor Binding Antibody result is greater than 0.4 nmol/L or Acetylcholine Receptor Blocking Antibody result is greater than or equal to 27% then Acetylcholine Receptor Modulating Antibody will be added at an additional charge. If Striated Muscle Antibody is greater than or equal to 1:40, then a titer will be added at an additional charge.

Clinical Info

In early-onset myasthenia gravis patients with anti-acetylcholine receptor antibodies, the presence of titin antibody indicates a 95 - 100% likelihood of an underlying thymoma.