Glomerular Basement Membrane IgG
Test Mnemonic
GBMBG
CPT Codes
- 83516 - QTY (1)
Aliases
- Anti-GBM Ab IgG, GBM Auto Antibodies
Performing Laboratory
ARUP
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL | Serum | SST (Gold) | Refrigerated | Separate serum from cells ASAP or within 2 hours of collection and transfer to standard aliquot tube. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 0.15 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | After separation from cells: 48 hours |
| Refrigerated | After separation from cells: 2 weeks |
| Frozen | After separation from cells: 1 year (Avoid repeated freeze/thaw cycles) |
Days Performed
Sun - Sat
Turnaround Time
2 - 3 days
Methodology
| Name | Description |
|---|---|
| Semi-Quantitative Multiplex Bead Assay |
Reference Range
| GBM Ab, IgG (Bead) | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | Negative: <=19 | AU/mL | Years | 99 Years | Normal | Equivocal: 20 - 25 | AU/mL | Years | 99 Years | Normal | Positive: >=26 | AU/mL |
Special Info
This test is New York DOH approved.
Clinical Info
The presence of anti-glomerular basement membrane (GBM) antibodies by multiplex bead assay may aid in the diagnosis of Goodpasture syndrome. False positive results may occur due to reactivity against other chains of type IV collagen. If multiplex bead assay is negative but there is strong suspicion for disease, renal biopsy may be indicated. A renal biopsy may also be essential in suspected Goodpasture disease with renal involvement, allowing diagnostic confirmation and assessment of renal prognosis.