Treponema Pallidum IgG




Test Mnemonic

TPAG

CPT Codes

  • 86780 - QTY (1)

LOINC ®

17726-1

Aliases

  • Syphilis serology confirmation

Includes

  • Treponema pallidum IgG

Performing Laboratory

Cleveland Clinic Laboratories


Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
2 mLSerumSST (Gold) Refrigerated 

Minimum Specimen Requirements

Volume Type Container Collect Temperature Transport Temperature Special Instructions
0.5 mL     

Stability

Environmental Condition Description
Ambient1 day
Refrigerated7 day
Frozen14 day

Days Performed

Mon, Wed, Fri

Turnaround Time

1 - 5 days

Methodology

Name Description
Enzyme Immunoassay (EIA) 

Reference Range

Special Info

Do not use heat inactivated samples. Do not use hyperlipemic, hemolytic, or contaminated samples. Avoid repeated freezing and thawing.

Clinical Info

This confirmatory test is typically used as part of the syphilis reverse sequence testing algorithm where screen test is reactive but RPR is non-reactive. In general: A negative result cannot exclude recent Treponemal infection if specimen collected within 7-10 days after appearance of suspect lesions or 2-3 weeks after an exposure. Clinical correlation is required. An equivocal result cannot exclude nonspecific reactivity or very recent Treponemal infection. Repeat testing is suggested 2-3 weeks after this draw if clinically warranted. A positive result suggests recent or past Treponemal infection. This test cannot distinguish venereal syphilis from endemic treponematoses. Final interpretation should be done in conjunction with treponemal confirmatory testing, RPR test result, and clinical correlation. Should further interpretation be needed, please page 84707.

Clinical Limitation

This test cannot distinguish venereal syphilis from endemic treponematoses. Final interpretation should be done in conjunction with treponemal confirmatory testing, RPR test result, and clinical correlation.