Neutrophil Cytoplasmic Antibody
Test Mnemonic
ANCA
CPT Codes
- 86036 - QTY (2)
Aliases
- ANCA
- Anti-Neutrophil Cytoplasmic Ab
Includes
- C-ANCA and P-ANCA by Indirect Immunofluorescence Assay
- If either is positive, Proteinase-3 Ab and Myeloperoxidase Ab by multiplex
Performing Laboratory
Cleveland Clinic Laboratories
FDA Category
In Vitro Diagnostic
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Serum | SST (Gold) | Refrigerated |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 24 hours |
| Refrigerated | 7 days |
| Frozen | 30 days |
Days Performed
Mon - Fri
Turnaround Time
1 - 4 days
Methodology
| Name | Description |
|---|---|
| Indirect Immunofluorescence Assay (IFA) |
Reference Range
| Myeloperoxidase Ab | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | < 1.0 | AI | |
| Proteinase-3 Ab | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Years | 99 Years | Normal | < 1.0 | AI |
Special Info
If either C-ANCA or P-ANCA are positive or questionable by IFA, then Proteinase-3 Ab and Myeloperoxidase Ab by multiplex will be performed and billed.
Clinical Info
Diagnosis and monitoring of patients with Wegener's Granulomatosis, systemic arthritis and glomerulonephritis. Also present in Polyarthritis Nodosa and other vasculitides. Atypical indirect immunofluorescence may be seen with inflammatory bowel disease and a common mediated liver disease, usually in the P-ANCA pattern