Metanephrines, Urine Random
Test Mnemonic
UMETRA
CPT Codes
- 83835 - QTY (1)
Includes
- Metanephrine
- Normetanephrine
- Metanephrine Total
Performing Laboratory
Cleveland Clinic Laboratories
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 10 mL | Urine, random | Clean container | Refrigerated | Adjust urine pH to 3 or less by adding 6M HCl in 1 mL increments if storage/transport will be greater than 24 hours from end of collection. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 3 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 7 days |
| Refrigerated | 2 weeks |
| Frozen | 1 month |
Days Performed
Tue, Fri
Turnaround Time
1 - 9 days
Methodology
| Name | Description |
|---|---|
| High Performance Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS) |
Reference Range
| Metanephrine | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0 - 227 | ug/g crt | |||
| Metanephrine Total | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 100 - 677 | ug/g crt | |||
| Normetanephrine | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 100 - 450 | ug/g crt |
Special Info
Adjust urine pH to 3 or less by adding 6M HCl in 1 mL increments if storage/transport will be greater than 24 hours from end of collection. Specimen stability is currently based on sample with a pH of 3 or less.
Clinical Info
Evaluate catecholamine production; diagnose pheochromocytoma. The total metanephrines is equal to the sum of metanephrine plus normetanephrine. Typically, patients with essential hypertension have total metanephrine results less than 1500 ug/24 hours. Total metanephrine results greater than 1500 ug/24 hours can be seen in life-threatening illness, intense physical exercise, or neuroendocrine tumors.
Clinical Limitation
Urine Metanephrine test performed by Liquid Chromatography Tandem Mass Spectrometry (LC-MS/MS). Results obtained with different methods or kits cannot be used interchangeably.