Platelet Neutralization
Test Mnemonic
PLTNEU
CPT Codes
- 85597 - QTY (1)
LOINC ®
40647-0
Aliases
- PNP
Performing Laboratory
Cleveland Clinic Laboratories
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 mL | Plasma | Sodium citrate (Lt. Blue) | Centrifuge, aliquot and freeze ASAP. | Discontinue heparin or direct thrombin inhibitor therapy 48 hours prior to collection. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Days Performed
Mon - Fri
Turnaround Time
1 - 3 days
Methodology
| Name | Description |
|---|---|
| Clotting Assay |
Reference Range
| Platelet Neutralization Delta | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | <1.9 | sec | |||
| PTT LA Mix | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 31.5-38.3 | sec | |||
| PTT LA Screen | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 30.2-43.0 | sec |
Special Info
3.2% sodium citrate is the preferred anticoagulant recommended by NCCLS. Indicate if patient is receiving heparin or coumadin or direct thrombin inhibitors.
Clinical Info
Discontinue heparin or direct thrombin inhibitor therapy 48 hours prior to collection. Test will not be performed if PTT is normal. The Platelet neutralization test is a confirmatory assay to detect the presence of a lupus anticoagulant. However, this test should not be used alone in the evaluation of lupus anticoagulant. Order circulating anticoagulant, dRVVT and hexagonal phase phospholipid neutralization tests for a more complete evaluation of lupus anticoagulant. These tests are available in the lupus anticoagulant panel, which includes an interpretation.