FISH for BCL2 (18q21) Tissue
Test Mnemonic
BCL2FT
CPT Codes
- 88377 - QTY (1)
Includes
- FISH for 18q21
Performing Laboratory
Cleveland Clinic Laboratories
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 2 slides | Slide (s), unstained | Clean container | Ambient | One formalin-fixed, paraffin embedded block containing representative tissue OR unstained 4 μm tissue sections on electrostatically charged slides containing representative tumor. Tissue must be fixed in formalin NOT B5 or PREFER fixative |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | Blocks and slides should be transported at ambient temperature. |
Days Performed
5 days per week
Turnaround Time
3 - 5 days
Methodology
| Name | Description |
|---|---|
| Fluorescent In-Situ Hybridization (FISH) |
Reference Range
Clinical Info
Interphase FISH analysis utilizing a dual color, break-apart probe for the BCL2 gene at 18q21.33. Rearrangements of the BCL2 gene are observed in various B-cell lymphomas. The translocation partner gene cannot be identified in this assay. If no cells are available for analysis, no analysis charges will be incurred.