Chromium, Urine
Test Mnemonic
UCHRO
CPT Codes
- 82495 - QTY (1)
Includes
- Chromium, Urine ratio to CRT
- Chromium, Urine per volume
- Chromium, Urine per 24 hour
- Creatinine, Urine per volume
- Creatinine, Urine per 24 hour
- Hours Collected
- Total Volume
Performing Laboratory
ARUP
FDA Category
Laboratory Developed Test
Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 8 mL | Urine, 24-hour (well-mixed) | Plastic container | Refrigerate during collection. | Refrigerated | Patient Prep: High concentrations of iodine may interfere with testing. Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, non-essential over-the-counter medications (upon the advice of their physician). Avoid iodinated or gadolinium-based contrast media for at least 72 hours or 14 days for patients with impaired kidney function. Collection: Collect in a plastic container, mix well and aliquot into a trace metal free transport tube (ARUP #43116). Record total volume and collection time interval on specimen. |
Alternate Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 8 mL | Urine, random | Plastic container | Refrigerated | Patient Prep: High concentrations of iodine may interfere with testing. Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, non-essential over-the-counter medications (upon the advice of their physician). Avoid iodinated or gadolinium-based contrast media for at least 72 hours or 14 days for patients with impaired kidney function. Collection: Collect in a plastic container, mix well and aliquot into a trace metal free transport tube (ARUP #43116). Record total volume and collection time interval on specimen. |
Minimum Specimen Requirements
| Volume | Type | Container | Collect Temperature | Transport Temperature | Special Instructions |
|---|---|---|---|---|---|
| 1 mL |
Stability
| Environmental Condition | Description |
|---|---|
| Ambient | 1 week |
| Refrigerated | 2 weeks |
| Frozen | 1 year |
Days Performed
Sun - Sat
Turnaround Time
2 - 6 days
Methodology
| Name | Description |
|---|---|
| Inductively Coupled Plasma / Mass Spectrometry (ICP-MS) |
Reference Range
| Chromium, urine - per volume | |||||
|---|---|---|---|---|---|
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.0 - 2.0 | ug/L | |||
| Chromium, urine (24hrs) | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.0 - 2.0 | ug/d | |||
| Chromium, Urine ratio to CRT | |||||
| Sex | Age From | Age To | Type | Range | Range Unit |
| Normal | 0.0 - 10.0 | ug/g crt |
Special Info
Patient Prep: High concentrations of iodine may interfere with testing. Diet, medication, and nutritional supplements may introduce interfering substances. Patients should be encouraged to discontinue nutritional supplements, vitamins, minerals, non-essential over-the-counter medications (upon the advice of their physician). Avoid iodinated or gadolinium-based contrast media for at least 72 hours or 14 days for patients with impaired kidney function. Collection: Collect in a plastic container, mix well and aliquot into a trace metal free transport tube (ARUP #43116). Record total volume and collection time interval on specimen. Urine transported in a non-trace element-free tube or contaminated with iodine, gadolinium, blood, fecal material or acid preservative will be rejected. This test is New York DOH approved.
Clinical Info
This test may be useful to monitor short term exposure. The form of chromium greatly influences distribution. Trivalent chromium resides in the plasma and is usually not of clinical importance. Hexavalent chromium is considered highly toxic. Symptoms associated with chromium toxicity vary based upon route of exposure and dose and may include dermatitis, impairment of pulmonary function, gastroenteritis, hepatic necrosis, bleeding, and acute tubular necrosis. The ACGIH Biological Exposure Index for daily exposure of hexavalent chromium is an increase of 10 µg/gCRT between pre-shift and post-shift urine collections. The ACGIH Biological Exposure Index for long and short-term hexavalent chromium is an end-of-shift concentration of 30 µg/gCRT at the end of the work week.